In another context, De Paula Pohl et al. developed a CAR-analogous, chimeric B-cell antibody receptor, called BAR, containing the immunodominant A2 domain of FVIII to generate BAR-Tregs targeting FVIII-specific B cells which are responsible for persistent anti-FVIII neutralizing antibodies (inhibitors) in hemophilia A patients [106]. Here, F8 is linked to hemophilia A.