F8 and hemophilia A: The co-expression of IL-10 as additional payload in HLA-A2 CAR-Tregs further enhanced their capacity to suppress alloresponses in vitro [168], although IL-10-overexpressing FVIII-CAR Tregs unexpectedly developed a robust effector phenotype and failed to control inhibitory immune responses in a murine model of hemophilia A [103].