To this end, the inhibition of Foxp3 negative regulators including the Deleted in Breast Cancer 1 (DBC1) protein or Janus kinase2 (JAK2), licensed Tregs to retain high Foxp3 expression and maintain their suppressive function in experimental models of autoimmunity and GvHD, respectively [138,139]. The gene discussed is CCAR2; the disease is Autoimmunity.