The underlying mechanism of FMD on the anti-cancer effect is that a decrease in the blood concentration of glucose, insulin and IGF1 causes IGF1R- protein kinase B(Akt)-mammalian target of rapamycin (mTOR) pathway downregulation [10,11], which leads to gene expression profile alterations that ultimately promote autophagy and cell death in cancer cells [12]. This evidence concerns the gene INS and cancer.