Moreover, the expression of ER tends to be more prevalent/intense in SLCTs compared to adult granulosa cell tumors while PR expression tends to be more prevalent/intense in adult granulosa cell tumors compared to SLCTs [189]; these markers could be helpful, especially for the differential diagnosis of poorly differentiated SLCTs and adult granulosa cell tumor, although ER/PR alone could not be used to differentiate between both neoplasms. The gene discussed is ESR1; the disease is granulosa cell tumor.