In contrast, in the case of histopathological suspicion of moderately/poorly differentiated SLCTs, the identification of a DICER1 variant could be used to rule out some differential diagnoses, such as sarcomatoid/poorly differentiated granulosa cell tumors, and, depending on the clinical characteristics (age, other tumor association), should lead to constitutional testing in order to not overlook a DICER1 syndrome. This evidence concerns the gene DICER1 and DICER1-related tumor predisposition.