MYC and medulloblastoma: Medulloblastoma cells were treated with EPZ015666 in a dose-dependent manner for 72 hr and the results of cell growth assays confirmed that EPZ015666 induced growth inhibition directly proportionate to the dose in all MYC-driven medulloblastoma cell lines at a low micromolar potency, with an IC50 of 1.5–2.5 μM [22].