PPARGC1A and colonic neoplasm: However, in mice with colon cancer that were subjected to moderate-intensity wheel-running for two weeks, mitochondrial biogenesis and activity were retained, as indicated by the upregulation of the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a), as well as the increased content of the mitochondrial succinate dehydrogenase (SDH) and the regulator of cellular respiration cytochrome c [134].