Eleven variants identified only one additional breast-cancer-affected carrier in the pedigrees in which they were identified (CHD5, DYSF, GZMA, AKAP11, MED14, EPHX1, SOX13, ACSS2, ACTL7A variant 1, SLCO1B3, and FBN1). The gene discussed is FBN1; the disease is breast carcinoma.