Recent findings suggest that WNT5a released from melanoma cells prompts paracrine WNT5-β-catenin signalling in DCs, resulting in an upsurge of the immunoregulatory enzyme indoleamine 2,3-dioxygenase-1 (IDO), which is pivotal in tumour-induced immune tolerance [38]. The gene discussed is WNT5A; the disease is neoplasm.