In colon cancer, interleukin-1 (IL-1) and TAMs collaborate to activate NF-κB-dependent PDK1/AKT signalling in tumour cells, inactivating glycogen synthase kinase 3 beta (GSK3β), amplifying Wnt signalling, and fostering colon cancer cell proliferation [39]. This evidence concerns the gene PDK1 and colonic neoplasm.