While nearly 80% of myeloma cells lines are dependent on the anti-apoptotic MCL1 protein or both MCL1 and BCLXL, which is an important survival protein in MM [46], MM with t(11;14) biology is characterized by an increased expression of BCL2 expression and diminished MCL1/BCLXL expression [46,51]. This evidence concerns the gene MCL1 and plasma cell myeloma.