DE analyses comparing the current E::R;pax5mut and the publicly available zebrafish B-ALL samples against the T-ALL zebrafish models revealed that the E::R;pax5mut samples clustered closely together with B-lineage and biphenotypic ALLs, expressing B-lineage-associated genes, including pax5, ebf1a, cd79a, cd79b, and syk, at significantly higher levels compared to the T-ALL fish. This evidence concerns the gene SYK and acute lymphoblastic leukemia.