Similarly, this study reveals Smad4KO BRAFV600E/+ β-cateningof organoids have the same invasive behaviors seen in Smad4KO BRAFV600E/+ tumor organoids, whereas BRAFV600E/+ β-cateningof organoids did not, suggesting that the loss of SMAD4 was critical for the invasive behavior. The gene discussed is SMAD4; the disease is neoplasm.