Independent pINDUCER-SMAD4 Smad4KO BRAFV600/+ tumor organoid lines were selected using puromycin (2 μg/mL), passaged, and treated for 48 h with doxycycline (dox, 4 μg/mL) to induce SMAD4 expression. This evidence concerns the gene SMAD4 and neoplasm.