It is interesting to note that although IL-8 has not been described as a factor involved in the polarization towards any TAN phenotype, previous studies have reported that HPV+ OSCC cells exhibit relatively low expression of IL-8, whereas HPV− cells increase its production [13], thus favoring the recruitment of neutrophils to the tumor site [26], increasing survival [28], and activating these granulocytes [27]. The gene discussed is CXCL8; the disease is neoplasm.