We evaluated the expression of the top five expressed lncRNAs in metastatic HNSCC, MASCC1, LOC653513, INS-IGF2, H19, and TNXA in 20 pairs of metastatic HNSCC and matched non-metastatic HNSCC tissues to validate the microarray analysis findings. The gene discussed is H19; the disease is head and neck squamous cell carcinoma.