Additionally, we observed that the exosomes from A549-Vector cells altered immune cell infiltration in the tumor microenvironment by reducing the proportions of neutrophils (CD11b+Gr-1+) and NK cells (CD3-CD49+) and increasing the proportion of CD86+ B cells (B220+CD86+) and CD80+ B cells (B220+CD80+) compared with PBS treatment (Figure 4D). The gene discussed is ITGAM; the disease is neoplasm.