In this study, we investigated if MGMT enhancer methylation is associated with common genetic variants in GBM patients, e.g., MGMT SNP rs16906252 C>T and telomerase reverse transcriptase (TERT) promoter mutations C228T and C250T, clinical parameters, e.g., proliferation index Ki-67, postoperative Karnofsky Performance Score (KPS), progression-free survival (PFS), and overall survival (OS), as well as age and sex of the patients. This evidence concerns the gene TERT and glioblastoma.