Other ERα-responsive genes that were upregulated in the E0771/bone ER-expressing BC line included Wisp2 (7.11-fold increase), Ltbp1 (6.10-fold increase), Bcl2 (5.02-fold increase), and Xbp1 (4.43-fold increase) (Supplemental Figure S1). Here, LTBP1 is linked to breast cancer.