The decreased immunoreactivity of SAV1 in the tumor specimens was associated with lymph node involvement (N0 vs. N1 + N2, p = 0.0022; Table 1; Figure 3C,D) and higher TNM disease stage (I + II vs. III + IV, p = 0.0034; Table 1; Figure 3C,D; Supplementary Figure S2) and histological grade (G2 vs. G3, p = 0.0489; Table 1; Figure 3E,F; Supplementary Figure S3). This evidence concerns the gene SAV1 and neoplasm.