A positive SAV1 immunohistochemical reaction was noted in the cytoplasm of epithelial cells (Figure 3A; Supplementary Figure S2A,C,E,G,I,K,M,O,Q,S; Supplementary Figure S3A,C,E,G,I,K), as well as in the CRC cells of the tissues studied (Figure 3B,C,E; Supplementary Figures S2B,D,F,H,J,R,T and S3B,D,F). Here, SAV1 is linked to colorectal carcinoma.