SAV1 and neoplasm: The average SAV1 mRNA expression was significantly downregulated in the tumor specimens compared to that observed in the non-cancerous tissue of the CRC patients and the colonic mucosa of the healthy subjects (0.5 ± 0.03 vs. 1.25 ± 0.08 and 1.00 ± 0.03, respectively; p < 0.0001; Figure 1B).