Figure 3A shows the images of xenograft tumors. Compared to the control group, the weight and volume of the tumors in the SOX2-OT knockdown group were significantly reduced, suggesting that the knockdown of SOX2-OT may reduce the tumorigenesis of HNSCC in vivo (Figure 3B,C). The gene discussed is SOX2; the disease is head and neck squamous cell carcinoma.