Immune checkpoints are also important targets in cancer immunotherapy, such as lymphocyte-activation gene-3 (LAG-3), T cell immunoglobulin and ITIM domain (TIGIT), V-domain Ig suppressor of T cell activation (VISTA), and T cell immunoglobulin and mucin-domain containing-3 (TIM-3) [17] (Figure 1). Here, TBXT is linked to cancer.