Along these lines, ephrin receptor A2 (EphA2) has been argued to be the main entry receptor for EBV into epithelial cells [91,92], and the E6 gene product of HPV18 was found to up-regulate EphA2 on immortalized esophageal carcinoma cells [93] (Figure 1D). This evidence concerns the gene EPHA2 and carcinoma of esophagus.