CD1D and neoplasm: On the other hand, it has been shown that the TME allows iNKT cells to directly exert anti-tumoral roles, particularly in ovarian cancer (OC), where iNKT were reported to be able to target the tumor through the recognition of CD1d, which was highly expressed by tumor-associated macrophages (TAMs) and myeloid-derived suppressive cells (MDSCs) [189].