All investigated cases received a calibrated score >0.99 for the methylation family “neuroblastoma”, with the results from representative cases of different genomic NB subgroups shown in Figure 4A. While the sample with a numerical-only profile was scored as subclass “TMM-negative”, all samples (n = 3) with ATRX aberrations received the highest score for subclass ALT/TERT TMM. This evidence concerns the gene ATRX and neuroblastoma.