Among the younger group, 53 had BRCA1/2 germline PVs/LPVs (38%), 15 were carriers of other cancer susceptibility genes (10%), primarily APC, NBN, ATM, MUTYH, MLH1, and only 2 patients were carriers of PVs/LPVs in both BRCA1/2 and other susceptibility genes (1%) (Figure 2). The gene discussed is APC; the disease is cancer.