Our data show that the number of endometrial cancer cell nuclei stained with γH2AX and co-localized with 53BP1 were significantly increased in DHODH inhibitor-treated cells versus untreated cells, HEC-1B: 31% versus 1.3% (** p < 0.01) and AN3CA: 52% versus 32% (*** p < 0.001), respectively (Figure 1A,B). Here, DHODH is linked to endometrial cancer.