In a transcriptome dataset of 18 paired ESCC patients, which included 18 adjacent normal esophageal tissues, 18 primary ESCC, and 14 metastatic lymph node cancer samples [26], we observed that the UGT2B15 was exclusively expressed in tumor tissues and metastatic lymph node samples (Figure 1A). Here, UGT2B15 is linked to esophageal squamous cell carcinoma.