Consistent with the role of JUN/FOSL2 directing AR transcriptional activation of UGT2B15 in ESCC, we found that depletion of JUN and FOSL2 significantly suppressed the invasion of both KYSE410 and ZEC014 cells without affecting cell proliferation (Figure 4D,E and Figure S2A–F). This evidence concerns the gene JUN and esophageal squamous cell carcinoma.