In this study, 42 tumor samples from 42 patients affected by PM were analyzed using a targeted amplicon-based panel identifying mutations in cancer-related genes such as EGFR, KRAS, BRAF, PIK3CA, NRAS, MEK1, AKT1, PTEN and HER2 and amplifications in EGFR, MET, PIK3CA, FGFR1 and FGFR2. This evidence concerns the gene PIK3CA and neoplasm.