BAP1 and pleural mesothelioma: Comprehensive multi-omics studies of pleural mesothelioma (PM) describe a genomic landscape mostly characterized by a lower number of somatic mutations inducing protein modifications and, conversely, a high level of copy number aberrations leading to functional losses in oncosuppressor genes such as BAP1, NF2, CDKN2A, SETD2 and TP53.