Regarding rheumatic diseases, a collagen-induced arthritis mouse model exhibited notable improvements in MMP-3 (Matrix Metalloproteinase-3), IL-17 (Interleukin-17), TNF-α, IL-1β (Interleukin-1 beta), IFN-γ, and IL-6 levels when mice were fed with an oleocanthal-rich diet. The gene discussed is IL1B; the disease is rheumatic disorder.