Our results demonstrate that the IGF-1 pathway is the main metabolic target for the anti-obesity effect of BPL1TM and LTA from BPL1TM while the genes jnk-1 and pmk-1, belonging to the JNK-1/DAF-16 pathway and p38 MAPK pathway, respectively, are not required. The gene discussed is IGF1; the disease is obesity due to melanocortin 4 receptor deficiency.