Furthermore, we have identified that BPL1TM, its heat treated form (BPL1TM HT) and its LTA prolong longevity in Caenorhabditis elegans (C. elegans) in an insulin/IGF-1-dependent mechanism, and its consumption improves the oxidative stress response, gut permeability and protection against pathogenic infections. The gene discussed is IGF1; the disease is infection.