The involvement of mitochondria in IBD has been previously described: swollen (less efficient) mitochondria and low levels of adenosine triphosphate (ATP) have been associated with changes in ileum permeability [6]; reduction in oxidative phosphorylation is observed in colon from IBD patients [7]; and mitochondrial Unfolded Protein Response (UPRmt), a mitochondrial stress pathway, is activated in intestinal epithelial cells from patients with IBD [8]. This evidence concerns the gene PROS1 and inflammatory bowel disease.