Curcumin and tannic acid provide neuroprotection in in vivo models of traumatic brain injury and cerebral ischemia-reperfusion via Akt and mTOR (mammalian target of rapamycin) and the Peroxisome proliferator-activated-receptor-gamma-coactivator-1alpha (PGC-1α)/Nrf2-ARE (antioxidant response element) signaling pathways [248,249]. This evidence concerns the gene MTOR and Cerebral ischemia.