NFKBIA and mood disorder: Therefore, considering the notable role played by the p-IKBα-NF-kB pathway in the development of chronic pain and mood disorders, our data suggest that the normalization of the overexpression of p-IKBα in the DRG and HIP produced by UFP-512 might be involved in the inhibition of allodynia as well as of the emotional and/or mechanical deficits produced by this DOR agonist.