The originality of the study is based on the inclusion of patients recently diagnosed with Class III and Class IV LN with a six-month follow-up where inflammatory markers (IL-6 and CRP), three oxidative stress markers (LPO, carbonyl groups in proteins and nitrites/nitrates), and the antioxidant activity of enzymes (SOD, CAT, TAC) contrasted to the found in HC were determined. This evidence concerns the gene CRP and lobular neoplasia.