CIS also decreased the protein levels of SOD-1 in the DRG of male (p < 0.005, one-way ANOVA; Figure 8B) and female mice (p < 0.002, one-way ANOVA; Figure 8D) vs. their respective VEH-VEH-treated animals but not in the PFC of male (p < 0.990, one-way ANOVA; Figure 8H) or female animals (p < 0.964, one-way ANOVA; Figure 8J). Here, SOD1 is linked to in situ carcinoma.