NLRP3 and early-onset autosomal dominant Alzheimer disease: In agreement with this, the administration of HRW also diminished the brain activation of the NLRP3 inflammasome and the expression of its downstream inflammatory molecules in a preclinical model of Alzheimer’s disease [76] and HRS reduced the levels of NLRP3 in the cortex of rats with subarachnoid hemorrhage [77].