NLRP3 and in situ carcinoma: Taking in to account the important contribution of inflammation and oxidative stress in the progress of CIS-induced neuropathy and/or in the physical and mental incapacities associated with it, the influence of the HRW treatment on the protein levels of the NLRP3 inflammasome and the oxidative stress marker 4-HNE in the DRG and PFC of CIS-injected male and female mice were evaluated (Figure 7).