NLRP3 and in situ carcinoma: Peripheral and central inflammatory reactions triggered by CIS were demonstrated by the enhanced levels of NLRP3 observed in the DRG (p < 0.010, one-way ANOVA; Figure 7A,C) and PFC (p < 0.002, one-way ANOVA; Figure 7G,I) from male and female mice compared with their respective VEH-VEH-treated mice.