HMOX1 and in situ carcinoma: Our data showed decreased expression of HO-1 in the DRG (p < 0.022, one-way ANOVA; Figure 8A,C) and PFC (p < 0.007, one-way ANOVA; Figure 8G,I) of male and female mice injected with CIS compared with their respective VEH-VEH-treated animals.