Previously, we reported that the agricultural waste of water caltrop hulls and isolated active compounds of the hydrolyzable tannins tellimagrandin-I and tellimagrandin-II inhibited AChE activities, anti-Aβ1-42 aggregation, and the anti-non-enzymatic glycation of AD-associated factors in vitro and enhanced learning behavior developments in scopolamine-induced ICR mice. Here, ACHE is linked to Alzheimer disease.