Colorectal cancerHuman adenocarcinoma colon cellsHCT116 (p53 wild type)HCT116 (p53 double knockout),SW480,LS174 (p53wild type)SCID mice xenograft model (injected with HCT116 p53 wild-type or p53 double knockout cells). The gene discussed is TP53; the disease is adenocarcinoma.