NUCB2 and obesity due to melanocortin 4 receptor deficiency: It was found that nesfatin-1 was undetectable in the VAT of normal-weight participants, but it was present in significant amounts in all the obese patients; this suggests that adipokine levels increase with obesity and are modulated by feeding and starvation, supporting the theory that nesfatin-1 is synthesized differentially in AT depending on the patient’s BMI [56].