The deleterious effects EVMetS, after neuronal RAS dysregulation towards the pro-oxidative/pro-inflammatory state, are consistent with previous studies showing the enhancing effect of AT1 overactivity on dopaminergic degeneration [16] and the neuroprotective effects of AT1 receptor blockers (ARBs) in cellular, animal [16] models of Parkinson ́s disease, and clinical studies [57,58]. Here, AGTR1 is linked to Parkinson disease.