IL6 and metabolic syndrome: In addition to the observation of a dysregulation in the EVMetS cargo towards the upregulation of the RAS pro-inflammatory axis, we confirmed the pro-inflammatory and pro-oxidative state of EVMetS by measuring the mRNA expression for the interleukins IL-6 and IL-1β and the NADPH-oxidase subunits p47phox and gp91phox, which were significantly increased in EVMetS rats relative to EVs from control rats and candesartan-treated MetS rats.