GPX4 and fibrosarcoma: As presented in Figure 4, HS reduced the mRNA expression of CAT, SOD1, SOD2, GSTT1, GSTA3, GPX1, GPX3, heme oxygenase-1 (HO-1), masculoaponeurotic fibrosarcoma F (MafF), MafG, MafK, selenoprotein S (SELENOS), SWLENOW, SELENOT, SELENOK, GPX4, ferritin heavy polypeptide-1 (FTH1), nuclear factor (erythroid-derived-2)-like 2 (Nrf2), and solute carrier family 7 member 11 (SLC7A11) (p < 0.05), and elevated the mRNA expression of Kelch-like ECH-associated protein 1 (Keap1) and post-transcriptional gene silencing-2 (PTGS2) (p < 0.01).