In our study, through integrated bioinformatics analysis using GEO datasets of bulk RNA profiling of lung fibroblasts isolated from IPF patients or bleomycin-treated mice, as well as single-cell RNA-seq of IPF patients and bleomycin-treated mice, we found evidence suggesting that TSP-1 is upregulated in lung fibroblasts during pulmonary fibrosis. The gene discussed is THBS1; the disease is pulmonary fibrosis.