In our study, through integrated bioinformatics analysis using GEO datasets of bulk RNA profiling of lung fibroblasts isolated from IPF patients or bleomycin-treated mice, as well as single-cell RNA-seq of IPF patients and bleomycin-treated mice, we found evidence suggesting that TSP-1 is upregulated in lung fibroblasts during pulmonary fibrosis. This evidence concerns the gene THBS1 and idiopathic pulmonary fibrosis.