PLOD1 and precocious puberty: In one case, a single pubertal level detected in multiple FMV U-LH determinations may serve as an indication to avoid a premature diagnosis of delayed puberty and to instead opt for a repeat series of FMV U-LH tests in due course; and in another, for instance, for a suspected precocious puberty, a clinician may require an early morning serum LH determination or a GnRH stimulation test based on the average of the two closest values.