The mechanisms through which CFRD detrimentally influences prognosis entail a combination of protein catabolism, reduced lean body mass, and malnutrition stemming from insulin inadequacy, along with an elevated pro-inflammatory and pro-infectious state correlated with intermittent hyperglycemia, as proposed by Sandouk et al. in 2021 [61]. The gene discussed is INS; the disease is Hyperglycemia.