Some illustrative examples include the notorious increase in the incidence of Hb E/β-thalassemia and β-thalassemia major in California between 1990 and 2000, which was attributed to the rise in Asian immigration [36], and the increase in the incidence of galactokinase deficiency in Germany from 1992 to 1999, which was attributed mainly to the influx of Bosnian refugees [37]. This evidence concerns the gene GSTM1 and hyperinsulinemic hypoglycemia, familial, 4.