Increases in CRP from pre-COVID1 to during COVID-19 (M = −1.43, SD = 4.23) and pre-COVID2 to during COVID-19 (M = −1.50, SD = 2.30) were greater than normative expected change in CRP during those same time periods (M = 3.43, SD = 2.80; t(9) = −4.74, p = 0.001, d = 1.59; M = 3.37, SD = 2.74; t(7) = −3.88, p = 0.006, d = 1.50), respectively. This evidence concerns the gene CRP and COVID-19.