SEMA4D and neoplasm: Representative upregulated (FGF1, MYC, and IL6) and downregulated genes (SEMA4D, PCDH20, and ISLR) are shown in Figure 2A. In addition, detailed upregulated genes associated with tumor proliferation are shown in Figure 2B. On the other hand, downregulated genes associated with reduced cell adhesion, signaling increased metastasis and migration of PDAC cells, are shown in Figure 2C.