It has been shown that amplification of the Her-2 gene often leads to increased expression of the Her-2 protein, which, in turn, activates the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) axis and mitogen-activated protein kinase (MAPK) cascade to induce cancer cell growth and invasion [13]. The gene discussed is ERBB2; the disease is cancer.