Compared with the East Asian population from GnomAD database, the AD patients in this study showed lower allele frequencies in three TCF3 SNPs, including rs1052692 (0.09 vs. 0.23), rs1052696 (0.10 vs. 0.23) and rs2074888 (0.27 vs.0.41). The gene discussed is TCF3; the disease is Alzheimer disease.