IgM and IgG responses in COVID-19 participants showed greater reactivity overall (both GCS = 15 and GCS ≤ 14), compared to the controls, with no difference in normalised fluorescence Z scores or the number of participants with IgG ‘hits’ (a Z-score >3) between those with normal or abnormal GCS score (Fig. 3a, b, Fig. 4a, b). The gene discussed is CD40LG; the disease is COVID-19.