To assess the role of SIRT6 in the pathogenesis of asthmatic airway remodeling, we initially detected the expression of SIRT6 and other sirtuin deacetylases (SIRT1-SIRT5, SIRT7) in the lung tissues in an experimental model of acute severe asthma (ASA) (Fig. 1a). The gene discussed is SIRT1; the disease is asthma.