To assess the role of SIRT6 in the pathogenesis of asthmatic airway remodeling, we initially detected the expression of SIRT6 and other sirtuin deacetylases (SIRT1-SIRT5, SIRT7) in the lung tissues in an experimental model of acute severe asthma (ASA) (Fig. 1a). This evidence concerns the gene SIRT7 and asthma.