In chromosome 17q-gained neuroblastoma, the JMJD6 gene is over-expressed due to both gene gain and transcriptional super-enhancers, and suppression of super-enhancer activity reduces JMJD6 gene expression, neuroblastoma cell proliferation in vitro and tumor growth in a mouse model [20] (Table 1). This evidence concerns the gene JMJD6 and neuroblastoma.