The N-terminal SNAG domain of the transcriptional repressor GFI1 binds to the CoREST transcriptional complex proteins LSD1 and RCOR1 at the enhancers of transcription factor genes, such as SPI1 (PU.1), CEBPA and IRF8 which are important for acute myeloid leukemia cell differentiation [14]. This evidence concerns the gene SPI1 and acute myeloid leukemia.