BRD4 and cancer: In human neck squamous cell carcinoma, BRD4 recruits Mediators and NF-κB at super-enhancers associated with cancer stemness genes such as MET, TP63 and FOSL1. Treatment with BRD4 inhibitors reduces stemness gene expression; suppresses cancer stem cell self-renewal, invasive growth and metastasis; and eliminates tumor cells and cancer stem cells in a mouse model of neck squamous cell carcinoma [36].