The other dual BRD4 and CBP/p300 bromodomain co-inhibitor NEO2734 up-regulates the expression of p53 and its target PUMA and induces colorectal cancer cell apoptosis through the intrinsic and extrinsic apoptosis pathways, suppression of the intrinsic or extrinsic apoptosis pathway partly rescues colorectal cancer cells, and NEO2734 represses colon cancer progression by inducing colorectal cancer cell apoptosis in a mouse model [63] (Table 2). Here, TP53 is linked to colorectal cancer.