BRD4 and nasopharyngeal carcinoma: In nasopharyngeal carcinoma cells, super-enhancers are enriched of BRD4, NF-κB, IRF1 and IRF2 transcription factors at the loci of critical oncogenes such as ETV6, high expression of which in human nasopharyngeal carcinoma tissues is correlated with poor patient prognosis [37].