Similarly, in diffuse intrinsic pontine glioma, the expression of critical oncogenic genes such as SOX2 and NOTCH1 is regulated by super-enhancers, and treatment with super-enhancer inhibitors reduces diffuse intrinsic pontine glioma cell proliferation in vitro and tumor progression in mouse models [21] (Table 1). This evidence concerns the gene NOTCH1 and diffuse intrinsic pontine glioma.