In alveolar rhabdomyosarcoma, the chimeric transcription factor PAX3-FOXO1 interacts with the master transcription factors MYCN, MYOG and BRD4 at target gene super-enhancers, resulting in over-expression of SOX8, MYOD1, MYOG and MYCN, alveolar rhabdomyosarcoma tumorigenesis and dependence on BRD4 [39]. The gene discussed is PAX3; the disease is rhabdomyosarcoma.