KDM1A and acute myeloid leukemia: GFI1 inactivation or LSD1 inhibition with small molecule compound inhibitors disrupts the interaction between GFI1, LSD1 and RCOR1, leading to considerable increase in H3K27ac at enhancer regions of the transcription factor genes, transcriptional activation, acute myeloid leukemia cell differentiation, growth inhibition and clonogenicity reduction [14].