ESR1 and neoplasm: RECQL deficient tumors with FOXP3+ T-cell infiltration within tumor cell nests (Table 2), within adjacent stroma (Supplementary Table 10), within distant stroma (Supplementary Table 10) and total FOXP3+ T-cells were all highly significantly associated with high grade, de-differentiation, pleomorphism, higher mitotic index, high Ki67 expression, high risk Nottingham prognostic index (NPI), ER-, PR- and triple negative breast cancers (all p values p≤0.0001).