ESR1 and neoplasm: RECQL deficient tumors with CD8+ T-cell infiltration within tumor cell nests (Table 1) or adjacent stroma (Supplementary Table 8) were highly significantly associated with larger tumors, high grade, de-differentiation, pleomorphism, higher mitotic index, high Ki67 expression, high risk Nottingham prognostic index (NPI), ER-, PR- and triple negative breast cancers (all p values ≤0.001) compared to RECQL proficient CD8- tumors.