When CD8+ T-cell infiltration was taken together (within tumor cell nest, adjacent and distant stroma), RECQL deficient tumors with total CD8+ T-cells were significantly associated with high grade, de-differentiation, pleomorphism, higher mitotic index, high Ki67 expression, high risk Nottingham prognostic index (NPI) and triple negative breast cancers (all p values ≤0.05) (Supplementary Table 9) compared to RECQL proficient CD8- tumors. This evidence concerns the gene MKI67 and neoplasm.