Engineered cell clones, TCGA-LIHC, and LICA-FR expression data of patients with chr8pLOH showed common deregulated pathways including metabolic pathways and several pathways associated with cancer metastasis and cell migration [actin cytoskeleton, transforming growth factor–β (TGF-β) signaling, focal adhesion, axonal guidance, and epithelial-mesenchymal transition (EMT); Fig. 3, B and C]. The gene discussed is TGFB1; the disease is cancer.